Pharmaceutical drugs, hazardous chemical compounds and other products must be evaluated for their hematological toxic potential for their safety use. In vitro CFU-GM clonogenic assay is one of the best test systems to evaluate the adverse toxic effects of xenobiotics on the blood forming system. The test involves exposing the mice bone marrow cells to various test substances at different concentrations and estimating the inhibition of the proliferation of the CFU-GM colonies. This technique is best use for determining the human maximum tolerated dose (MTD). It describes the use of in vitro CFU-GM assay for characterizing and predicting hazards to humans.
This paper describes our first undergraduate project experience, final report and findings on the subject matter. Initially according to our project title, we were focused on developing a low cost detector which can detect radiation only. To make one of these kinds of detector doesn’t take much and can be prepared at fairly low cost being very common project in nuclear science arena. The Geiger-Muller tube, or GM tube, is an extremely useful and inexpensive way to detect radiation. While the GM tube can only detect the presence and intensity of radiation, this is often all that is needed.